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USE OF QUINIDINE IN TREATMENT OF CHRONIC AURICULAR FIBRILLATIONResults Obtained in a Series of One Hundred Fifty-Five Patients
ERNEST H. YOUNT, M.D.;
MARVIN ROSENBLUM, M.D.;
ROBERT L. McMILLAN, M.D.
AMA Arch Intern Med. 1952;89(1):63-69.
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DURING recent years, considerable interest in the management of patients with chronic auricular fibrillation has developed. Previously, it was believed that this arrhythmia was merely a manifestation of the unfavorable progress of severe heart disease, and that in itself it did not materially affect the health of the patient or interfere with his cardiac efficiency.1 Now, however, abundant evidence, both clinical and experimental, supports the view that auricular fibrillation does have deleterious effects upon the circulation. In experimental animals, several groups of investigators2 have demonstrated a decrease in cardiac output during auricular fibrillation. Blumgart and Weiss,3 as well as Stewart and his associates,4 have reported that the rate of blood flow is reduced by as much as 20 to 68%. After the restoration of sinus rhythm, the blood flow returned to normal. Blood gas studies during and after auricular fibrillation indicate that cardiorespiratory efficiency is greater with a normal sinus rhythm,
. . . [Full Text PDF of this Article]
Author Affiliations
WINSTON-SALEM, N. C.
From the Department of Internal Medicine of the Bowman Gray School of Medicine of Wake Forest College.
Footnotes
This investigation was supported (in part) by a research grant from the National Heart Institute, United States Public Health Service.
Read before the Section on Experimental Medicine and Therapeutics at the One Hundredth Annual Session of the American Medical Association, Atlantic City, June 14, 1951.
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