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T. C. PRENTICE, M.D.; N. I. BERLIN, M.D.; J. H. LAWRENCE, M.D.

AMA Arch Intern Med. 1952;89(4):584-590.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT HAS LONG been known that marked increases in total blood volume occur in polycythemia vera and that the increase is due primarily to an increase in the total red cell volume.¹ Relatively little, however, has been written concerning serial determinations of the blood volume, total red cell volume, and plasma volume during therapy of this disease. Brown and Giffin^1a were the first to report on this phase; they studied five patients treated with phlebotomy and x-rays, doing two or three determinations on each patient. Later Haden² studied one patient, and shortly thereafter Gibson and associates^1b reported on a series of three patients studied in a similar manner. Of the nine patients followed by these three groups, eight showed an over-all fall in total red cell volume, associated with a fall in red blood cell count and hemoglobin concentration. The fall in total red cell volume was accompanied with a . . . [Full Text PDF of this Article]

Author Affiliations
BERKELEY, CALIF.

From the Section on Experimental Medicine, Donner Laboratory of Medical Physics, University of California, Berkeley, Calif.

Footnotes
Dr. Prentice is Atomic Energy Commission Post-Doctorate Research Fellow.

This study was supported by a grant from the United States Public Health Service.

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