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A Series of Twenty Consecutive Cases

PAUL A. BUNN, M.D.; GEORGE PEABODY, M.D.

AMA Arch Intern Med. 1952;89(5):736-742.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE RATIONALE for employing large doses of parenterally administered penicillin as a standard method of therapy for pneumococcal meningitis was first stated by Dowling and his group in 1949.¹ Their observations on a small series of 21 cases indicated that 1,000,000 units of aqueous crystalline penicillin administered intramuscularly every two hours was superior to all other previously described regimens of therapy for the disease.² It was their opinion that the use of intrathecally administered penicillin and/or the combination of a sulfonamide with penicillin was unnecessary, although in patients in coma on admission a single initial intrathecal dose of penicillin may be given. Dowling's recommended program for the therapy of pneumococcal meningitis has been followed in a small series of patients treated in this institution, and the results lend further proof to his original contention.

METHODS

The hospital courses of 20 consecutive patients^2a with bacteriologically proved pneumococcal meningitis . . . [Full Text PDF of this Article]

Author Affiliations
SYRACUSE, N. Y.

From Department of Medicine, State University of New York at Syracuse College of Medicine.

Footnotes
This study was supported by a grant from Bristol Laboratories, Inc., Syracuse, N. Y.

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