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AMA Arch Intern Med. 1952;89(5):853-855.

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GENERAL NEWS

American Trudeau Society Medical Section of the National Tuberculosis Association

CURRENT STATUS OF ISONICOTINIC ACID HYDRAZIDE IN THE TREATMENT OF TUBERCULOSIS

The Executive Committee of the American Trudeau Society has reviewed the available evidence on the antituberculous activity of isonicotinic acid hydrazide as presented by Hoffmann-La Roche, Inc., E. R. Squibb & Sons, and investigators cooperating with them. On the basis of this evidence, the Committee makes the following statement for the guidance of the medical profession:

1. Chemical Structure:

Isonicotinic acid hydrazide ("nydrazid," trade name of E. R. Squibb & Sons; "rimifon," trade name of Hoffmann-LaRoche, Inc.) is a chemically pure, synthetically produced substance of the general formula C₆H₇N₃O.

It is obtained in almost colorless crystals which are highly soluble in water. A closely related derivative, which is also being studied for its antituberculous properties, is the isopropyl derivative ("marsilid," trade name of Hoffmann-La Roche, Inc.).

Isonicotinic . . . [Full Text PDF of this Article]

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