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EDWIN R. FISHER, M.D.; A. C. CORCORAN, M.D.

AMA Arch Intern Med. 1952;89(6):943-950.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ESTABLISHMENT of experimental hypertension by compression of one or both renal arteries with a metal clamp¹ directed attention to lesions of main renal arteries as causes of hypertension in man. Some investigators² believed that they could demonstrate at autopsy a high incidence of arteriosclerotic narrowing in fixed preparations of renal arteries from hypertensive patients. However, Lisa and associates³ could not show a relation between the level of arterial pressure during life and the caliber of the renal arteries in fresh preparations. Yuille⁴ reviewed the relation between lesions of main renal arteries and hypertensive disease and discounted the participation of renal arteriosclerosis in the genesis of this condition. He pointed out that the lesions of large vessels were commonly associated with intrarenal arteriolar sclerosis and that both were presumably results and not causes of hypertensive disease. Had the arterial lesions been primary, then, as in experimental renal hypertension in rats,⁵ arteriolar . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Department of Pathology and Research Division of the Cleveland Clinic Foundation and Frank E. Bunts Educational Institute.

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