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STUDIES IN MITRAL STENOSISThe Effect of Ouabain on the Circulation in Patients with Pulmonary Disability
RICHARD A. BLOOMFIELD, M.D.;
BERNARD RAPOPORT, M.D.;
J. PERVIS MILNOR, M.D.;
WALTER K. LONG, M.D.;
J. GILMER MEBANE, M.D.;
LAURENCE B. ELLIS, M.D.
AMA Arch Intern Med. 1952;89(6):970-977.
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DIGITALIS substances are usually employed in the treatment of patients with mitral stenosis who display clinical symptoms of either marked dyspnea or peripheral congestion. The clinical responses of these patients to such therapy may be gratifying, but not infrequently the drugs appear to exert no beneficial effect and may even be deleterious. The reasons for such varying responses to this therapeutic measure are poorly understood by most clinicians, who are likely to employ broad generalizations in their attitudes regarding the use of digitalis in mitral stenosis, varying from never giving it to giving it routinely in all cases. The variable response to the drug in mitral stenosis can be understood better on consideration of the fact that the disabilities resulting from rheumatic heart disease with mitral stenosis vary greatly in their physiologic and anatomic nature. The fundamental lesion in mitral stenosis is a narrowing of the mitral orifice, resulting in
. . . [Full Text PDF of this Article]
Author Affiliations
With the Technical Assistance of Rita Lavin BOSTON
From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School.
Footnotes
This study was supported by the Life Insurance Medical Research Fund and the National Heart Institute.
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