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CEREBRAL METABOLIC DISTURBANCE AND DELIRIUM IN PERNICIOUS ANEMIAClinical and Electroencephalographic Studies
DONALD C. SAMSON, M.D.;
SCOTT N. SWISHER, M.D.;
RICHARD M. CHRISTIAN, M.D.;
GEORGE L. ENGEL, M.D.
AMA Arch Intern Med. 1952;90(1):4-14.
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IT IS THE purpose of this paper to discuss the disturbance in cerebral function which occurs in pernicious anemia patients. This aspect of the disease process, while noted since the earliest descriptions of the disease, has remained poorly understood because of the lack of tools for proper study of such cerebral processes.
HISTORICAL REVIEW
In his classical description of pernicious anemia in 1849, Addison1 may have recognized disturbance in cerebral function in the disease process, for he wrote as follows:
Its approach is first indicated by a certain amount of languor and restlessness, to which presently succeed a manifest paleness of countenance, loss of muscular strength, general relaxation or feebleness of the whole frame, and indisposition to, or incapacity for, bodily or mental exertion.
Lichtheim2 in 1887 first called attention to neurodegenerative changes in pernicious anemia and ascribed them to some blood-circulating toxin. In a poorly received paper,
. . . [Full Text PDF of this Article]
Author Affiliations
SYRACUSE, N. Y.; ROCHESTER, N. Y.
From the Departments of Medicine and Psychiatry, Strong Memorial Hospital and Rochester Municipal Hospital, University of Rochester School of Medicine and Dentistry.
Footnotes
Commonwealth Fund Fellow in Medicine and Psychiatry (Dr. Samson).
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