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SAMUEL ZELMAN, M.D.

AMA Arch Intern Med. 1952;90(2):141-156.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EXPERIMENTAL obesity produced by hypothalamic injury in various species of animals is uniformly accompanied with liver damage, progressing occasionally to cirrhosis.¹ In hereditarily obese strains of mice, liver damage is also seen uniformly, and even tumors of the liver are observed.² Although the increased incidence in human obesity of gall-bladder disease³ and diabetes mellitus⁴ has long been known, and although these conditions may lead independently to liver disease, there does not appear to be in the literature a consideration of the existence of liver damage in obesity per se. The majority of obese persons show a significant decrease in carbohydrate tolerance,⁵ and this impairment has been related to the duration rather than to the degree of obesity.⁶ Similar decreases in carbohydrate tolerance are observed in the experimental obesity of hypothalamic injury¹ and in hereditarily obese mice.⁷ Newburgh and Conn⁸ suggested that the disturbed carbohydrate metabolism occurring with obesity is related . . . [Full Text PDF of this Article]

Author Affiliations
TOPEKA, KAN.

From the Medical Service, Winter Veterans Administration Hospital.

Footnotes
Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the author are the result of his own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

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