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ESCHERICHIA COLI ENDOCARDITISReport of a Case Presenting a Difficult Problem in Chemotherapy
CHARLES M. ROSS, M.D.;
JAMES D. WHEELER, M.D.;
PAUL O. HAGEMANN, M.D.
AMA Arch Intern Med. 1952;90(2):258-265.
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WELL-AUTHENTICATED instances of endocarditis due to Escherichia coli are uncommon, only 14 such cases having been reported.1 All these cases have met the logical criteria suggested by Harries and Burtenshaw1e and by Hoffman and associates,1i namely: (1) positive blood cultures obtained during the life of a patient with a compatible clinical picture and (2) demonstration of the organism in the cardiac valves at necropsy.
Two additional patients with this condition have been reported on, both of whom recovered after streptomycin therapy.2 For these patients the diagnosis was made on the basis of clinical evidence plus positive blood cultures. Recoveries following other types of antibiotic therapy have not been recorded. It seems reasonable that, with newer antibiotic agents, more successful results will be reported in the future. In these circumstances, cases satisfying the first criterion would have to be accepted as proved. Microscopic examination of the heart valves in successfully treated
. . . [Full Text PDF of this Article]
Author Affiliations
ST. LOUIS
From the Departments of Medicine and Pathology, Washington University School of Medicine and the Barnes Hospital.
Footnotes
Dr. Ross is Assistant in Clinical Medicine; Dr. Wheeler is Resident in Pathology, and Dr. Hagemann is Assistant Professor of Clinical Medicine.
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