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A Study of Normal and Abnormal Responses

HOWARD E. TEWELL, Jr., M.D.; J. STUART PRITCHARD, M.D.

AMA Arch Intern Med. 1952;90(4):435-443.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DIAGNOSIS of coronary artery disease in the presence of a normal resting electrocardiogram has been aided by the use of tests designed to create a relative hypoxemia of the myocardium, the best known of which are the Master two-step test¹ and the anoxemia test of Levy.² The former method relies upon a standardized amount of exercise based on age, weight, and sex to create a greater demand for oxygen by the myocardium, whereas the anoxemia test decreases the amount of oxygen to the heart through the inhalation of a 10% oxygen mixture for a 20-minute period. The electrocardiographic changes which occur with these procedures in the presence of coronary disease are reflected mainly by RS-T segment depressions and/or T wave inversions in one or several leads. These alterations are similar in both tests and are thought to be due to factors common to the effects of exercise . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Northwestern University College of Medicine and the Department of Medicine, Wesley Memorial Hospital.

Footnotes
Dr. Tewell was formerly resident in medicine and Dr. Pritchard is resident in medicine, Wesley Memorial Hospital.