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Investigation of a Case, Including Isolation of Some Hitherto Undescribed Porphyrins

ALASTAIR G. MACGREGOR, M.D., M.R.C.P.; R. E. H. NICHOLAS, Ph.D., A.R.I.C.; C. RIMINGTON, Ph.D., D.Sc.

AMA Arch Intern Med. 1952;90(4):483-504.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WALDENSTRÖM¹ has divided the porphyrias into the following groups:

1. Porphyria congenita, a familial disease, probably recessive in character, present at birth and characterized by sensitivity to light, pigmented bones and teeth, and greatly increased coproporphyrin and uroporphyrin excretion, mainly of Series I.
   
2. Porphyria cutanea tarda, a disease in which the porphyrinuria and sensitivity to light develop later in life and a sclerodermic tendency is noticeable. The occurrence of colic and the occasional excretion in the urine of uroporphyrin suggest a relationship with the group next to be described. Severe nervous symptoms have not yet been reported.²
   
3. Porphyria acuta, a familial disease, dominant in character, accompanied with the excretion of coproporphyrin and uroporphyrin mainly of Series III. The following clinical forms have been recognized: (a) Latent porphyria in which there is increased uroporphyrin excretion without any clinical manifestations of porphyria; such patients as have been encountered have always been
   

Author Affiliations
SHEFFIELD, ENGLAND; LONDON, ENGLAND

From the Department of Pharmacology and Therapeutics, University of Sheffield, Sheffield, England, and the Department of Chemical Pathology, University College Hospital Medical School, London, England.

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