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Report of Four Cases

MIKKO VIRKKUNEN, M.D.

AMA Arch Intern Med. 1952;90(5):580-586.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE BENEFICIAL effect of corticotropin (ACTH) and cortisone in drug hypersensitivities is well known,¹ but only a few reports have been published on their usefulness in severe hypersensitive blood abnormalities. The efficacy of corticotropin and cortisone in agranulocytosis has been confirmed by Caldwell and co-workers² and by McMillin.³ In the case reported by the former, treatment with cortisone was successful; the latter author described a rapid and complete remission with corticotropin therapy in a case of severe agranulocytosis. In both patients agranulocytosis resulted from sulfonamide therapy. Attempts to control thrombocytopenia with corticotropin or cortisone have given varying results. Combes and Costello⁴ have reported a case in which severe thrombocytopenia with purpura and mucosal hemorrhage was arrested by treatment with cortisone. In patients with idiopathic thrombocytopenic purpura remissions induced by the administration of corticotropin or cortisone have also been reported⁵; on the other hand, there arecases in which no improvement . . . [Full Text PDF of this Article]

Author Affiliations
HELSINKI, FINLAND

From the Medical Department of the Kivelä Hospital.

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