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DEMOS C. TRIANTAPHYLLOPOULOS, M.D.; BURTON A. WAISBREN, M.D.

AMA Arch Intern Med. 1952;90(5):653-659.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE REPORT of Moldavsky, Hasselbrock, and Cateno¹ that penicillin hastened the coagulation of blood has been confirmed by some workers and denied by others. The work of Macht² and the clinical impressions of Kemler,³ Ochsner and DeBakey,⁴ Frada,⁵ and Pelz⁶ supported the original findings, while the studies of Lewis,⁷ Weiner, Zeltmacher, and Shapiro⁸ and Dolkart and co-workers,⁹ Fleming and Fish,¹⁰ and Szczeklik and co-workers¹¹ failed to demonstrate a significant effect on any of the coagulation mechanisms tested. Observations of Hines and Kessler,¹² Axtrup,¹³ and Lewitus¹⁴ that in certain instances penicillin actually inhibited certain phases of coagulation have not been confirmed by other workers.^9c

Although editorials and review articles have emphasized that the question of an effect of penicillin on blood coagulation has yet to be settled, certain textbooks already have warned against the use of penicillin because of its supposed effect on coagulation.¹" The present study was done to determine . . . [Full Text PDF of this Article]

Author Affiliations
MILWAUKEE

From the Milwaukee County General Hospital and the Department of Medicine of Marquette University Medical School.

Footnotes
This study was aided by a grant from Chas. Pfizer & Company, Inc., Brooklyn 6.

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