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ARNO G. MOTULSKY, M.D.; SYLVAN WEINBERG, M.D.; OTTO SAPHIR, M.D.; EDWARD ROSENBERG, M.D., Ph.D.

AMA Arch Intern Med. 1952;90(5):660-676.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SYSTEMIC involvement of lymphoid tissue is a well-recognized feature of rheumatoid arthritis.¹ Among patients with rheumatoid arthritis, 50 to 75% may be found to have palpable lymph nodes.² These nodes usually are painless, nontender, discrete, and movable under the skin. They may vary from small pea-sized structures to sizable lymph nodes (up to 3 cm.) which immediately attract clinical attention. They may be at the usual sites of clinically discernible lymph node enlargement, such as in the axillary, epitrochlear, cervical, and inguinal areas. Some patients, however, show enlarged lymph nodes at unusual sites, such as along the course of vascular channels of mid-arm or mid-thigh.³ It is now generally believed⁴ that the lymph node involvement represents participation of the lymphatic apparatus in the systemic disease, which rheumatoid arthritis is believed to be, rather than regional lymphadenopathy secondary to drainage from diseased joints. This belief is further strengthened by the finding . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Departments of Internal Medicine and Pathology, Michael Reese Hospital, Chicago. The Department of Pathology is in part supported by the Michael Reese Research Foundation.

Footnotes
Read in part before the meeting of the American Rheumatism Association, Atlantic City, N. J., June 8 and 9, 1951.

This study was aided by a grant from the National Institutes of Health, United States Public Health Service (RG 2522), to the Rheumatoid Arthritis Research Group of this hospital (Chairman, S. Soskin).

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