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Use of Penicillin, Including Aerosol, Dust, and Diethylaminoethyl Iodide Penicillin; and Aureomycin, Terramycin, and Chloramphenicol in Bronchiectasis, Bronchitis, Sinusitis, Bronchial Asthma and Pulmonary Emphysema

ALVAN L. BARACH, M.D.; HYLAN A. BICKERMAN, M.D.; GUSTAV J. BECK, M.D.

AMA Arch Intern Med. 1952;90(6):808-849.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE INTENTION of this paper is to appraise the value of antibiotic treatment in chronic bronchial infections. Patients with bronchial asthma and pulmonary emphysema frequently suffer from associated chronic bronchitis. In other cases of chronic bronchitis bronchospasm of slight to moderate extent is often present. Similarly, patients with bronchiectasis at times manifest bronchospasm and variable degrees of pulmonary emphysema. The results of treatment of these clinical entities with penicillin, especially by inhalation, and with aureomycin, terramycin, and chloramphenicol (chloromycetin®) will be presented, as well as a preliminary statement of the use of the diethylaminoethyl ester of penicillin.

The use of antibiotic drugs in bronchiectasis has been restricted in some clinics to the treatment of febrile episodes and the preparation of these patients for surgery.¹ Although the management of chronic infection in bronchopulmonary disease poses complex problems, the use of the antibiotic agents and procedures which are now available results in . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Medicine, Presbyterian Hospital, Columbia University College of Physicians and Surgeons, and the Columbia Division, Goldwater Memorial Hospital.

Footnotes
This article has been shortened for publication in the Archives by the omission of Table 3. This will appear in the authors' reprints.

The diethylaminoethyl ester of penicillin was furnished by the Smith, Kline & French Laboratories.

The soluble tablets of crystalline penicillin, which have been found convenient for aerosol administration by patients at home, were supplied to us by the Commercial Solvents Corporation and the Premo Pharmaceutical Laboratories, Inc.

The antibiotic drugs aureomycin, terramycin, and chloramphenicol (chloromycetin®) were supplied by the Lederle Laboratories Division, American Cyanamid Company; Charles Pfizer & Company, Inc., and Parke, Davis & Company. Penicillin was provided by E. R. Squibb & Sons and by Sharp & Dohme, Inc. The funds employed in the investigation were contributed by Cornelius Crane Jr., and by the Josiah Macy Jr. Foundation.

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