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S. R. WEINBERG, M.D.; P. A. TABENKIN, B.S.

AMA Arch Intern Med. 1952;90(6):850-857.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A CYSTINE calculus represents a chemical precipitation of a definite crystalloid, cystine, (S.CH₂.CH[NH₂].COOH)₂, when its concentration in solution passes a certain critical level. The solubility of cystine has been determined by previous chemical studies.¹ Figure 1 depicts the solubility of cystine at various pH levels, according to Sano. Figure 2 indicates the solubility change with temperature.

Reference to the solubility curves shows that at pH 7 cystine will be held in solution up to a concentration of 16.2 mg. per 100 at body temperature, but at pH 8 35.3 mg. per 100 cc. can be held in solution.

The urinary cystine excretion in normal persons varies from 0.8 to 84 mg. a day.² A patient with cystinuria excretes 400 to 1,000 mg. per day. The urine of such persons may or may not be supersaturated with cystine, depending upon the urinary volume and pH. This explains why not all persons . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Urology Service, Veterans Administration Hospital, Frank C. Hamm, M.D., Director.

Footnotes
Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

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