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GORDON B. MAGILL, M.D.; JOHN H. KILLOUGH, PH.D., M.D.

AMA Arch Intern Med. 1953;91(2):204-211.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ALTHOUGH there have been significant advances in the therapy of acute brucellosis in the past few years, the incidence of post-treatment relapses has remained a problem. In a previous study reported by us there was a relapse rate of 69% following the administration of any one of three antibiotics for an average period of 12 days.¹ Subsequently, efforts to reduce the incidence of relapse proceeded along two lines. One was to prolong administration of a single antibiotic.² The other was to use a combination of oxytetracycline ("terramycin") and streptomycin, an approach suggested by the apparent synergism between streptomycin and either aureomycin³ or oxytetracycline.⁴ The present paper reports a study of the latter method in which combined oxytetracycline-streptomycin therapy was administered to 23 patients with acute or subacute brucellosis. The results demonstrate that this form of therapy effects a marked reduction in relapse rate.

MATERIALS AND METHODS

Patients.

—Of the 23 . . . [Full Text PDF of this Article]

Author Affiliations
CAIRO, EGYPT

From the United States Naval Medical Research Unit No. 3.

Footnotes
These studies were made possible by the cooperation of the Egyptian Ministry of Health.

This article has been released for publication by the Division of Publications of the Bureau of Medicine and Surgery of the United States Navy. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large.

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