
HEPATOLENTICULAR DEGENERATIONReview of the Literature and Report of a Case with Dimercaprol (BAL) Therapy
M. MURRAY SCHECHTER, M.D.;
CHARLES A. JONES, M.D.
AMA Arch Intern Med. 1953;91(4):541-549.
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PROGRESSIVE lenticular degeneration (hepatolenticular degeneration, Wilson's disease) has been described as a rare disease involving the basal ganglion system and characterized by a chronic progressive fatal course. This disease is probably not so rare as was previously believed. One or two patients may be found in almost every city, and frequently in such cases the erroneous diagnosis of multiple sclerosis or paralysis agitans (Parkinsonism) is made. Recently, interest has been revived in this disease because of the possibility of a new and effective therapeutic agent. Occasional reports of small groups of patients treated with dimercaprol (Bal— 2,3-dimercaptopropanol) have been published in recent years. The most prominent of such reports is the one of Denny-Brown and Porter,1 in which they observed improvement in five patients who were subjected to repeated courses of dimercaprol. Our purpose in this report is to add an additional case report of a patient treated with
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Author Affiliations
NEW ORLEANS
From the Veterans Administration Hospital, New Orleans; Resident in Medicine (Dr. Schechter); Chief, Medical Service (Dr. Jones).
Footnotes
Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.
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