EFFECT OF NITROGEN MUSTARD ON CLINICAL COURSE OF GLOMERULONEPHRITIS
DAVID S. BALDWIN, M.D.;
PRESTON G. McLEAN, M.D.;
HERBERT CHASIS, M.D.;
WILLIAM GOLDRING, M.D.
AMA Arch Intern Med. 1953;92(2):162-167.
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REMISSIONS in the nephrotic phase of glomerulonephritis occur spontaneously and may follow intercurrent infections. Blumberg and Cassady1 and Janeway and associates2 have reported that transient reduction in protein excretion and diuresis may follow acquired or induced measles in patients in the nephrotic phase of glomerulonephritis. Since remissions might be related either to factors present in the plasma of patients with acute infections or to disturbances in renal hemodynamics which accompany fever,3 we examined the effects of the infusion of plasma from patients acutely ill with bacterial infections as well as the effects of typhoid vaccine-induced pyrogenic reaction in patients with glomerulonephritis but failed to induce a remission.4 Becker5 has demonstrated that the administration of methyl-bis (β-chloroethyl) amine hydrochloride (nitrogen mustard) prevents the development of the Shwartzman phenomenon in rabbits. Schwab and associates6 have reported that experimental nephritis in rabbits produced by the administration of bovine serum gamma globulin can be
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
From the Department of Medicine, New York University College of Medicine and the Third (New York University) Medical Division, Bellevue Hospital.
Footnotes
This study was supported by a grant from the New York Heart Association.
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