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Results of a Three-Year Study of Seven Hundred Tests in Many Disease States

EDMUND L. DUBOIS, M.D.

AMA Arch Intern Med. 1953;92(2):168-184.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DESCRIPTION by Hargraves of the L. E. cell five years ago gave a great impetus to the study of systemic lupus erythematosus.¹ The frequency of the disease and the variability of its clinical picture have since been emphasized by numerous workers using the L. E. test to verify their diagnosis. It is the purpose of this paper to present a simplified technique for the production of L. E. cell preparations which has been in use at the Los Angeles County General Hospital for three years and to compare its results with others in general use. In my experience the test is pathognomonic if positive.² Since we began utilizing this method, the diagnosis of lupus has increased four-fold at this hospital. Negative preparations occur in 30% of typical clinical cases of systemic lupus erythematosus.^2d Our experience with this technique in a series of 72 cases of lupus . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES

From the Department of Internal Medicine, University of Southern California, School of Medicine, and the Los Angeles County General Hospital.

Footnotes
This work was supported by a grant from Mr. Joseph H. Gluckstein and Merck & Company, Inc. Cortisone and hydrocorticosterone (Compound F) were generously supplied by Elmer Alpert, M.D., of Merck & Company, Inc., and I. Winter, M.D., of G. D. Searle & Company.

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