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A. F. COBURN, M.D.; L. V. MOORE, M.D.; J. HANINGER, M.D.

AMA Arch Intern Med. 1953;92(2):185-188.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

NIAZI and State¹ reported that the serum level of a substance which reacts with diphenylamine was elevated in several disease states, including rheumatic fever. Likewise, when a patient's serum was heated with Dische's diphenylamine reagent Ayala and his associates² observed an association between the intensity of the purple reaction and the degree of rheumatic activity. The present report includes a study of the diphenylamine values in three groups of children with carefully observed rheumatic fever. One group was treated in a uniform manner during the acute illness; a second group received several types of therapy following admission to the hospital; another was a group of children with quiescent rheumatic fever, who were attending school and receiving no treatment.

METHODS

Technique for Determining Serum Diphenylamine Values.

—The semimicro procedure described by Ayala, Moore, and Hess has been employed throughout this study.³ In this procedure, 5 ml. of 5% . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Rheumatic Fever Research Institute, Northwestern University Medical School.

Footnotes
Dr. Moore died March 5, 1953.

This study was supported by grants from the Victoria Foundation and from the United States Public Health Service.

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