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A Medical and Legal Problem

IRVING B. BRICK, M.D.

AMA Arch Intern Med. 1953;92(2):221-227.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT IS MORE than 10 years since the recognition of the epidemic of homologous serum hepatitis that followed the use of yellow fever vaccine which contained, as a diluent, human serum. That many lots of this particular vaccine were icterogenic has been documented by many observers, notably Sawyer and his associates,¹ Capps and his associates,² and Hayman and Read.³ Recently, Stebbins⁴ has reviewed from the epidemiologic point of view the implications of this experience. While certain lots of vaccine were shown to be highly icterogenic,¹ none of the donors of the serum used in these lots had experienced jaundice or hepatitis within nine months prior to the donation, although all had had jaundice sometime in the past. It appears that a chronic carrier state may develop in persons suffering from viral hepatitis and that the infectious agent may be carried in the blood in sufficient virulence to produce illness in . . . [Full Text PDF of this Article]

Author Affiliations
WASHINGTON, D. C.

From National Rehabilitation Commission, The American Legion, and Department of Medicine, Georgetown University School of Medicine.

Footnotes
This paper was presented in part at the Annual Meeting of the Association for the Study of Liver Diseases, Chicago, Nov. 1, 1952.

Dr. Brick is Assistant Professor of Medicine, Georgetown University School of Medicine, and Medical Consultant, National Rehabilitation Commission, The American Legion.

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