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Jacob Grossman, M.D.

AMA Arch Intern Med. 1953;92(4):459-463.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DURING the past fifteen to twenty years, studies of the pathogenesis of congestive heart failure have been directed primarily at the mechanisms responsible for the impaired renal excretion and/or retention of extracellular electrolytes and water. As a result, most advances in therapy have been concerned with the prevention of fluid accumulation and the facilitation of removal of excessive fluid. Since the organic mercurial diuretics provide the most rapid and efficient means of removing salt and water, their use has increased considerably. The availability of subcutaneously administerable preparations¹ whose ease of administration and predictability of action have led to the advocacy of self administration in selected patients² has contributed further to the growing use of these agents. The promise of oral mercurial diuretics, as yet unfulfilled, may lead to still greater usage.

Certain properties common to the presently used mercurials contribute to their inherent safety. Intravenous administration is now . . . [Full Text PDF of this Article]

Author Affiliations
Medical Division, Montefiore Hospital, N. Y.

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