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FENTON SCHAFFNER, M.D.; GEORGE C. TURNER, M.D.; DOROTHY E. ESHBAUGH, M.D.; WILLIAM B. BUCKINGHAM, M.D.; HANS POPPER, M.D., Ph.D.

AMA Arch Intern Med. 1953;92(4):490-493.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE LEVEL of gamma globulin in the serum is elevated in chronic inflammatory conditions even though the disease may be localized in a single organ. This has been related to the antibody response on the part of the host. However, this excess gamma globulin is by no means all antibody but is rather an "inert reaction globulin,"¹ which is only one expression of a generalized nonspecific reaction involving many organs. The availability of newer and simpler biochemical methods and biopsy techniques makes it possible to try to correlate structural and functional alterations in the living patient. This study represents the attempt to find the remote structural changes in pulmonary tuberculosis which are related to the level of the gamma globulin in the serum. In addition, the significance of serum gamma globulin elevation in estimating the extent of the nonspecific host reaction in the liver is evaluated.

MATERIAL AND METHODS . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Oak Forest Tuberculosis Hospital, Oak Forest, Ill., and the Hektoen Institute for Medical Research of the Cook County Hospital.

Footnotes
Supported by a grant from the Tuberculosis Institute of Chicago and Cook County.

Presented in part before the American Society of Experimental Pathology, Chicago, April 7, 1953.

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