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Preliminary Results in Experimental and Clinical Leukemia

HARRY SHAY, M.D.; CHRIS ZARAFONETIS, M.D.; NATHAN SMITH, M.D.; IRVING WOLDOW, M.D.; DAVID C. H. SUN, M.D.

AMA Arch Intern Med. 1953;92(5):628-645.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT IS NOW nearly two hundred years since Horace Walpole coined the term serendipity, which he in part borrowed from the title of an old legend, the "Three Princes of Serendip," who, so the story goes, went forth into the world and made discoveries of things they were not in search of through "chance" or "sagacity." The results that we have to report may well be considered as gains from serendipity, for they indirectly derive from attempts started about six years ago to produce glandular gastric cancer in rats by inducing gastric ulcer and instilling methylcholanthrene daily into the stomach through a rubber catheter. No gastric cancers were produced in this manner, but instead from these experiments there developed two useful experimental tools, one, adenocarcinoma of the breast,¹ and the other, four types of leukemia. These leukemias include an acute lymphatic² and a chronic myelongenous (chloro) leukemia,³ . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Samuel S. Fels Research Institute and Temple University Hospital, Temple University School of Medicine, St. Christopher's Hospital and Einstein Medical Center, Northern Division.

Footnotes
Research Fellow, Fels Research Institute (Dr. Sun).

Read before the Section on Experimental Medicine and Therapeutics at the 102nd Annual Session of the American Medical Association, New York, June 3, 1953.

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