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A Possible Factor in Certain Types of Diabetes

I. J. PINCUS, M.D., D.Sc.; J. Z. RUTMAN, B.S.

AMA Arch Intern Med. 1953;92(5):666-677.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WITHIN the past 30 years tremendous strides have been made in our understanding of the pathways of intermediary metabolism and, more recently, in the study of the metabolic disturbances which may occur in disease. Despite the many studies which have been performed since the isolation of insulin, an understanding of the biochemical disturbances which occur in the diabetic patient is not forthcoming. The earlier concept, that this syndrome is produced by a simple insulin deficiency, has given way to the belief¹ that in some instances various other factors may play a role. Among these may be glucagon, the hyperglycemicglycogenolytic factor.

Soon after Banting and Best² extracted insulin from the pancreas, it became apparent that the crude preparations available contained an impurity which caused a rise in blood sugar level. Bürger and his co-workers³ and Collens, Murlin, and their associates⁴ studied this "contaminant," which they called glucagon. After Abel⁵ succeeded in . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Physiology and Division of Endocrine and Cancer Research, Jefferson Medical College, and Department of Gastroenterology, Graduate School of Medicine, University of Pennsylvania.

Footnotes
Supported in part by a research grant from Eli Lilly & Company, Indianapolis.

Read before the Section on Pathology and Physiology at the 102nd Annual Session of the American Medical Association, New York, June 3, 1953.

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