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Previously Undescribed Cell Findings in Paget's Disease (Osteitis Deformans)

MICHAEL A. RUBINSTEIN, M.D.; AMMIEL SMELIN, M.D.; ALBERT L. FREEDMAN, M.D.

AMA Arch Intern Med. 1953;92(5):684-696.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SIR JAMES PAGET'S classic report¹ on osteitis deformans was followed by numerous investigations² which have established the protean clinical manifestations, the specific pathological picture, the biochemical alteration, and the roentgenographic abnormalities which characterize this condition whose causation still remains obscure. Although the clinical diagnosis is often made readily, at times there may be great difficulty in differentiating Paget's disease from other bone disorders, especially from osteoblastic cancer metastases.³

In this communication, hitherto undescribed cell findings in bone marrow aspirates will be reported. These cell findings were noted in eight consecutive cases of Paget's disease and consist of large mononuclear cells and giant multinucleated syncytial forms, both of which have unique morphological characteristics. The detailed cytology of these cells and their significance will be presented below.

INITIAL OBSERVATIONS

Early in 1952, an iliac bone marrow smear from a patient (Case 1) with suspected pernicious anemia was examined by . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK; BROOKLYN

From the Division of Neoplastic Diseases and the Medical Division, Montefiore Hospital.

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