This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Observations on Experimental Use of Neohydrin (1347EX), a Chloro Derivative, and Two Thiol (1353EX and 1431EX) Derivatives of 2-Methoxy-Propylurea

JOHN H. MOYER, M.D.; CARROLL A. HANDLEY, Ph.D.; RICHARD A. SEIBERT, Ph.D.; HARVEY B. SNYDER, M.D.

AMA Arch Intern Med. 1953;92(6):847-855.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ALTHOUGH mercurials exhibit diuretic properties when given orally,¹ the diuresis produced has generally been considered to be inadequate and inferior to that obtained following use of the parenteral route,² and for this reason the oral route of administration has not been very popular. However, several recently synthesized mercurial diuretics have been shown to exhibit greater diuretic potency than meralluride (Mercuhydrin).³ With the development of more active compounds it seemed worth while to investigate the diuretic potential of these three experimental mercurials when administered by the oral route. The three compounds under investigation are (1) Neohydrin (3-chloromercuri-2-methoxypropylurea [1347Ex]), (2) 3-carboxymethyl-mercaptomercuri-2-methoxypropylurea (1353 Ex), and (3) 3-(a-carboxyethylmercaptomercuri)-2-methylpropylurea (1431Ex). Observations were made on the effect of oral administration of these compounds on water and electrolyte excretion in both normal subjects and in patients with cardiac failure. In addition, mercury excretion studies were performed on patients and on dogs.

METHODS AND MATERIALS

Clinical observations were . . . [Full Text PDF of this Article]

Author Affiliations
HOUSTON, TEXAS

From the Departments of Pharmacology and Medicine, Baylor University, College of Medicine.

Footnotes
Supported in part by a grant from the Houston Heart Association, the Lakeside Laboratories, Inc., and the M. D. Anderson Foundation.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?