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G. E. WAKERLIN, Ph.D., M.D.

AMA Arch Intern Med. 1953;92(6):889-896.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PATHOGENESIS of essential hypertension is still unknown, although progress toward an answer has been made in the past 20 years. According to one view, hypertension is a sign of disease, as are fever and leucocytosis, and "essential" is expressive of our ignorance of its pathogenesis; on this basis, essential hypertension should be regarded as a term comparable to "fever of unknown origin." This view suggests that essential hypertension may be a genus composed of several still undifferentiated species or types of hypertension, which formerly included the hypertensions due to pheochromocytomas, adrenocortical tumors, and renal abnormalities. Another view regards essential hypertension as a definite disease entity with varied manifestations chiefly dependent upon the body areas of localization and degree of progress of the underlying vascular disease process. While this concept is held by a minority of those working in the field, presently available evidence is as supportive of a single . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Physiology, University of Illinois College of Medicine.

Footnotes
The hypertension research group, headed by Dr. Wakerlin, is presently supported by grants from the National Heart Institute of the United States Public Health Service (Grant H428 C3), the American Heart Association, the Chicago Heart Association, and the University of Illinois Foundation.

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