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GERALD T. PERKOFF, M.D.; AVERY A. SANDBERG, M.D.; DON H. NELSON, M.D.; FRANK H. TYLER, M.D.

AMA Arch Intern Med. 1954;93(1):1-8.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE NUMEROUS clinical and laboratory techniques that have been devised to study the functional activity of the various endocrine glands give ample testimony to the difficulty of critically evaluating endocrine function. For the estimation of the adequacy of adrenal function various metabolic processes related to effects of adrenal steroids may be studied. Some of these are the ability to excrete a water load, determinations of serum electrolytes, and observation of the blood sugar during fasting. Urinary 17-ketosteroids are in part derived from adrenal secretions but show a relatively poor correlation with adrenal function.¹ Techniques are also available for the measurement of the urinary excretory products of the 17,21-dihydroxy-20-ketone steroids, but problems related to the relative proportions degraded and excreted unchanged present themselves in the evaluation of such data.¹ Salt deprivation and insulin tolerance tests lack specificity and are laborious and potentially dangerous. The eosinophile response to adrenocorticotropin (ACTH) has been extremely useful . . . [Full Text PDF of this Article]

Author Affiliations
SALT LAKE CITY

From the Departments of Medicine and Biochemistry and the Laboratory for the Study of Hereditary and Metabolic Disorders, University of Utah.

Footnotes
Dr. Nelson's present address is Naval Medical Center, Bethesda, Md.

Dr. Perkoff is Research Fellow in Medicine, University of Utah, and Senior Assistant Surgeon, National Institutes of Arthritis and Metabolic Diseases, National Institutes of Health, Department of Health, Education, and Welfare, Bethesda, Md.

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