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Its Activity in Protecting the Gastroduodenal Mucosa Against Peptic Ulceration

FRANKLIN HOLLANDER, Ph.D.

AMA Arch Intern Med. 1954;93(1):107-120.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Why DOES the living stomach of a warm-blooded animal not digest itself? This question has intrigued physiologists for almost two centuries, yet it still constitutes one of the major mysteries of our science. To some people, the problem may seem to be purely academic—one that might have fascinated the medieval philosophers, had they had a suitable conception of the process of digestion to start with. In actuality, however, the answer to this question is the key to the etiology of peptic ulceration, because this disease process is essentially just such a process of autodigestion. In the normal person, digestion of the gastrointestinal mucosa by his own gastric juice is evidently prevented by the operation of some protective mechanism, but in the ulcer patient this agent appears to have suffered impairment, at least in isolated areas. Hence, the answer to our question rests entirely on the character and action of this . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Gastroenterology Research Laboratory, The Mount Sinai Hospital.

Footnotes
This paper is part of a research project supported by grants from the National Cancer Institute, National Institutes of Health, United States Public Health Service.

A preliminary report was presented at the XVIII International Physiological Congress, Copenhagen, August 1950, and was published in the Abstracts of Communications of the Congress.

Read before the joint meeting of the Section on Gastroenterology and Proctology and the Section on Pathology and Physiology at the 102nd Annual Meeting of the American Medical Association, New York, June 4, 1953.

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