This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

JESSE W. HOFER, Ph.D., M.D.; GREGORY M. McCASKEY, M.D.

AMA Arch Intern Med. 1954;93(1):44-52.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE LAST decade witnessed the golden age in the isolation, purification, and manufacture of antibiotic drugs. A wide variety of bacterial, rickettsial, and some viral diseases can now be selectively treated and cured with these antimicrobial agents. While the advantage gained by the clinician is great, there are new problems to confront him. Among these are the superinfections caused by secondary organisms resistant to the antibiotic drug currently employed in treating a primary sensitive pathogen.

The disturbances of the usual bacterial ecology induced by the administration of antibiotics have been described.¹ Alterations of this kind have been noted in the mouth, throat, upper respiratory tract, intestinal canal, vagina, and perhaps in the skin. While the usual microbial population maintains a delicate balance between the various types, antibiotic therapy favors the multiplication of certain members of the bacterial population. Therapy directed toward infections caused by Grampositive bacteria may allow or . . . [Full Text PDF of this Article]

Author Affiliations
HOUSTON, TEXAS

From the Department of Medicine, Baylor University College of Medicine, Veterans Administration Hospital, and Jefferson Davis Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?