This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Beneficial Therapeutic Effect of Polymyxin B in Meningitis Due to Organisms of the Colon Group

J. PARK BIEHL, M.D.; MORTON HAMBURGER, M.D.

AMA Arch Intern Med. 1954;93(3):367-378.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ONE PARTICULAR method whereby ordinarily noninvasive organisms of low virulence may produce clinical disease is their inadvertent introduction into various areas of the body during certain procedures. If the area is poorly controlled by host defences, the organism may flourish and frank infection may ensue. Thus, superficial infections of the urinary tract may result from contamination during instrumentation, and, similarly, meningitis may be produced by the injection of contaminated material into the cerebrospinal fluid. Meningitis due to Pseudomonas aeruginosa has followed simple lumbar puncture*; the injection of serum,⁷ unsterile solutions of spinal anesthetics, or antibiotics, and pneumoencephalography, in which the air passed through a contaminated water trap. Infected craniospinal wounds, surgical and traumatic, have also resulted in Pseudomonas meningitis.|| The mortality in untreated cases is substantial.

Recent success in treating Pseudomonas meningitis with polymyxin B¶ has prompted us to review five such cases, seen recently at the Cincinnati General Hospital . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI

From the Department of Medicine, University of Cincinnati College of Medicine and the Cincinnati General Hospital.

Footnotes
Read by title before the Central Society for Clinical Research, Chicago, Nov. 7 and 8, 1952.

The antibiotics used in this study were provided as follows: chlortetracycline (Aureomycin) by Dr. Stanton M. Hardy, Lederle Laboratories Division, American Cyanamid Company; oxytetracycline (Terramycin) by Dr. Gladys Hobby, Chas. Pfizer & Company, Inc; polymyxin B (Aerosporin) by Dr. Donald S. Searle, Burroughs Wellcome & Company, Inc.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?