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Report of Two Cases

CRAIG N. SMITH, M.D.; JOHN STAIGE DAVIS, Jr., M.D.

AMA Arch Intern Med. 1954;93(4):629-632.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN AN ATTEMPT to develop a long-acting repository form of pencillin various modifications of ordinary benzyl penicillin have been prepared in an effort to maintain suitable therapeutic concentrations in the body. Jensen and his co-workers* in 1948 successfully developed a diethylaminoethyl ester hydriodide of penicillin G which, although it was found in low cencentrations in the plasma after intramuscular injection, did appear in high concentrations in sputum and lung tissue. This was ascribed to a specific organ affinity of the unhydrolyzed ester, which on hydrolysis in lung tissue liberated free penicillin and diethylaminoethyl alcohol. Comparison studies in patients with equal amounts of penicillin procaine, penicillin sodium, and the diethylaminoethyl ester hydriodide of penicillin G revealed a five to eight times greater sputum concentration with the latter drug.

Animal studies have shown⁶ unusually high penicillin concentrations in the brain tissue of those treated with this ester. More important, Wellman . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Medicine, St. Luke's Hospital.

Footnotes
References 1 and 2.

References 3-5.

Neo-Penil is the trademark of Smith, Kline & French Laboratories, Philadelphia, for the diethylaminoethyl ester hydriodide of penicillin G.

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