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C. J. WATSON, M.D.

AMA Arch Intern Med. 1954;93(5):643-657.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT HAS been known for many years that the urine Ehrlich reaction is strongly positive in cases of acute porphyria. This was generally interpreted as due to excessive urobilinogen until 1931, when Paula Sachs¹ clearly distinguished this substance from the Ehrlich-reacting chromogen in porphyria urines. She based the distinction on differences in solubility and the failure of the porphyria chromogen upon oxidation to exhibit green fluorescence with zinc acetate. Rather, it was oxidized to a brown pigment differing from urobilin and believed to represent what the older literature had rather vaguely designated as "urofuscin." Waldenström² spoke of this as the "red pigment," and still later Waldenström and Vahlquist³ studied the chromogen in more detail, confirming the observation that, unlike urobilinogen, it is not extracted from urine by most organic solvents. They noted that the Ehrlich aldehyde compound, in addition to the strong absorption band at 550 to . . . [Full Text PDF of this Article]

Author Affiliations
With the Technical Assistance of Violet Hawkinson, B.S., and Irene Bossenmaier, B.S. MINNEAPOLIS

From the Department of Medicine, University of Minnesota Medical School and Hospital.

Footnotes
Presented in part before the Association of American Physicians, Atlantic City, N. J., May 5, 1953.

Supported in part by the John and Mary Briggs Fund for research on Porphyria and under contracts with the Atomic Energy Commission and the Surgeon General's Office, United States Army, under sponsorship of the Commission on Liver Disease, Armed Forces Epidemiological Board.

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