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TETRACYCLINE THERAPYClinical and Laboratory Observations on One Hundred Eighty-Four Patients Treated with Tetracycline
WALTER S. WOOD, M.D.;
GILBERT P. KIPNIS, M.D.;
HAROLD W. SPIES, M.D.;
HARRY F. DOWLING, M.D.;
MARK H. LEPPER, M.D.;
GEORGE GEE JACKSON, M.D.
AMA Arch Intern Med. 1954;94(3):351-363.
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TETRACYCLINE is a recently developed antibiotic which has a structure2 and antimicrobial spectrum * similar to those of chlortetracycline and oxytetracycline. To evaluate its clinical usefulness and pharmacologic properties, we have studied the effect of the oral and intravenous administration of tetracycline, as the hydrochloride, in 184 patients with acute infections.
All adults were given a dose of 2 gm. a day, and children were given 50 mg. per kilogram of body weight a day, in four divided doses at six-hour intervals. The adult patients treated orally were given an initial dose of 1 gm., and the children were given a dose of 25 mg. per kilogram of body weight, for the purpose of obtaining a higher initial serum level.
The clinical course in 153 of the 184 patients was evaluated on the basis of duration of fever, leucocytosis, subjective complaints, and objective physical findings (Table 1). The response of
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO
From the Research and Educational Hospitals, University of Illinois College of Medicine, and the Municipal Contagious Disease Hospital.
Footnotes
Tetracycline (Achromycin) was made available through the courtesy of Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y.
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