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TREATMENT OF ACUTE LEUKEMIA WITH CORTISONE AND CORTICOTROPIN
PHAEDON FESSAS, M.D.;
M. M. WINTROBE, M.D.;
R. B. THOMPSON, M.D.;
G. E. CARTWRIGHT, M.D.
AMA Arch Intern Med. 1954;94(3):384-401.
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ALTHOUGH the usefulness of the hormones corticotropin and cortisone in the treatment of acute leukemia has become quite clear, little consideration has been given to the possible reasons for the effectiveness of these agents in some cases and their failure in others. We have become impressed that in certain cases the course of the illness has even seemed to become accelerated in association with such hormone therapy. A review of our own experience was therefore initiated and the present report represents the results of that study.
REVIEW OF LITERATURE
A review of the literature reveals that others have made somewhat similar observations, although a critical analysis of experience in a single clinic has not been published. In Table 1 a summary is given of the recorded data. Unfortunately, a number of investigators have not attempted to differentiate the various types of acute leukemia. Others have done so, but criteria for
. . . [Full Text PDF of this Article]
Author Affiliations
SALT LAKE CITY
From the Department of Medicine, College of Medicine, University of Utah.
Footnotes
This investigation was supported in part by a research grant, C-2349, from The National Cancer Institute, of the National Institutes of Health, Public Health Service.
Fellow of the Damon Runyon Memorial Fund for Cancer Research (Dr. Fessas) and Commonwealth Fund Fellow; present address, University of Durham Medical School, King's College, Newcastle-upon-Tyne, England (Dr. Thompson).
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