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J. Q. GRIFFITH, Jr., M.D.; F. DeEDS, Ph.D.; J. NAGHSKI, Ph.D.; C. F. KREWSON, Ph.D.

AMA Arch Intern Med. 1954;94(6):1037-1044.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CLINICAL studies on the application of rutin in the treatment of spontaneous capillary fault associated with hypertension in humans ¹ have demonstrated that a minority of subjects (approximately 12%) failed to respond to rutin therapy, in spite of a wide range in dosage.

Since pharmacological studies had indicated that the physiological activity of rutin resides in the flavonol moiety, that is, the quercetin portion of the molecule, it seemed advisable to submit quercetin to clinical testing.²

Principally, this Exhibit is a report of these clinical investigations with quercetin and includes results of related chemical and pharmacological studies. . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

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