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I. Familial Metaphyseal Dysplasia and Craniometaphyseal Dysplasia; Their Relation to Leontiasis Ossea and Osteopetrosis; Disorders of "Bone Remodeling"

W. P. U. JACKSON, M.D.; FULLER ALBRIGHT, M.D.; GARTH DREWRY, M.D.; JOSEPH HANELIN, M.D.; MITCHELL I. RUBIN, M.D.

AMA Arch Intern Med. 1954;94(6):871-885.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DEVELOPMENT of a bone is a complicated process. A long bone arises from a solid mass of mesenchyme which turns into a strong but delicate and light tubular structure, constantly adapting its architecture to the needs of bodily growth and stresses and strains.

METAPHYSEAL DYNAMICS

The metaphysis of a bone is that part of its shaft which adjoins the epiphysis; we do not attempt to define its exact extension in the other direction. It is that part of the bone where the effect of recent events is often shown—the transverse lines produced by any serious illness, the dense bands of elemental phosphorus poisoning, the chondromas arising from nests of trapped epiphyseal cartilage cells, and so forth. It is particularly here that deficient molding and remodeling of a growing bone may be seen. Thus, the normal graceful and rapid tapering from the wider epiphysis to the narrower tubular shaft . . . [Full Text PDF of this Article]

Author Affiliations
CAP TOWN, UNION OF SOUTH AFRICA; BOSTON; MINNEAPOLIS; BOSTON; BUFFALO

From the Department of Medicine of the Harvard Medical School, Medical Service of the Massachusetts General Hospital, and the Children's Hospital, Buffalo.

Footnotes
The expense of these studies was defrayed by grants from Ayerst, McKenna and Harrison, Ltd.; the American Cancer Society, on the recommendation of the Committee on Growth of the National Research Council, and the National Cancer Institute, National Institutes of Health.

Eli Lilly Research Fellow, 1953; lately Assistant in Medicine at the Massachusetts General Hospital and Harvard University; at present with Department of Medicine, University at Cape Town (Dr. Jackson); Resident in Radiology, University of Minnesota Hospital (Dr. Drewry); Associate Radiologist, Department of Radiology, Massachusetts General Hospital (Dr. Hanelin); Pediatrician-in-Chief, The Children's Hospital, Buffalo (Dr. Rubin).