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II. Multiple Epiphyseal Dysplasia; Its Relation to Other Disorders of Epiphyseal Development

W. P. U. JACKSON, M.D.; JOSEPH HANELIN, M.D.; FULLER ALBRIGHT, M.D.

AMA Arch Intern Med. 1954;94(6):886-901.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MULTIPLE epiphyseal dysplasia, described by Barrington-Ward in 1912,¹ has achieved recognition as a clear-cut clinical entity through the work of Fairbank.* It may masquerade under the title multiple osteochondritis, bilateral Legg-Perthes disease, Morquio's disease, stippled epiphyses, Kaufman's hyperplastic chondrodystrophy, or even cretinism. Earlier reports are reviewed (in German) by Jansen ⁹ and Ribbing.¹³

The disorder consists essentially of irregularity in form and structure of the developing epiphyses, which usually appear two to three years late. Multiple centers of ossification may develop at different times in the same epiphysis, but the extreme stippling of punctate epiphyseal dysplasia ³ does not occur. The affection is bilateral and nearly symmetrical. It progresses toward consolidation, so that successive roentgenograms demonstrate improvement with age. Epiphyseal union is generally little delayed. After puberty some abnormal- ity of epiphyseal shape or joint angulation may bear witness to the previous cartilaginous dysplasia. The bone in adult . . . [Full Text PDF of this Article]

Author Affiliations
CAPE TOWN, UNION OF SOUTH AFRICA; BOSTON

From the Department of Medicine of the Harvard Medical School and the Medical Service and the Department of Radiology of the Massachusetts General Hospital.

Footnotes
Eli Lilly Research Fellow, 1953; lately Assistant in Medicine at the Massachusetts General Hospital and the Harvard Medical School; present address, Department of Medicine, University of Cape Town (Dr. Jackson).

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