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ARTHUR J. MERRILL, M.D.; JOSEPH WILSON, M.D.; LLOYD F. TIMBERLAKE, M.D.

AMA Arch Intern Med. 1954;94(6):925-930.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INTERMITTENT treatment with adrenocorticotropic hormone, first described by Farnsworth,¹ is a definite milestone in the management of the nephrotic syndrome. Diuresis is accomplished in 45 to 80% of the cases,* and in many improvement is maintained. Those who require repeated courses, however, swing from an edematous state to a dehydrated, washed-out, debilitated condition and are rarely well enough to live normal lives. They eat voraciously at times and are anorectic at others.

In the summer of 1951, when a 3-year-old child failed to have her usual diuretic response following a 12-day course of corticotropin (ACTH) treatment was resumed at a lower dosage level for two more weeks, after which complete diuresis occurred. The child (L. H.) had had a series of 10 courses by March 3, 1952. Between courses albuminuria would disappear, only to reappear in a few days followed by edema. She was never well enough to permit . . . [Full Text PDF of this Article]

Author Affiliations
ATLANTA

Footnotes
Read before the Section on Experimental Medicine and Therapeutics at the 103rd Annual Meeting of the American Medical Association, San Francisco, June 22, 1954.