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Its Uses and Side-Effects in 2,502 Patients

WILLIAM P. BOGER, M.D.; S. CLYDE STRICKLAND, M.D.

AMA Arch Intern Med. 1955;95(1):83-92.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PROBENECID (Benemid) * resulted from a prolonged research effort directed toward the discovery of a safe agent that, administered orally, would physiologically inhibit the renal tubular secretion of penicillin.¹ Introduced into clinical medicine on July 22, 1949,² the use for which it was intended has increased steadily, and new indications for the drug have been disclosed. A conservative estimate indicates that 4,000,000 patient days (15,626 patient years) of therapy have been administered. Granting that the record of side-effects following the use of any therapeutic agent is not static, and that continuing use will bring to light an increasing number of side-effects and toxic manifestations, an appraisal from time to time seems appropriate. A preliminary assessment of the toxicity of probenecid was presented in 1951 on the basis of 701 patients,⁴⁹ and it is now possible to report on 2,502 patients. The information reported here has been derived from . . . [Full Text PDF of this Article]

Author Affiliations
Norristown, Pa.

From the Department of Research Therapeutics, Norristown State Hospital.

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