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CHLORPROMAZINE AS A THERAPEUTIC AGENT IN CLINICAL MEDICINE
JOHN H. MOYER, M.D.;
VERNON KINROSS-WRIGHT, M.D;
R. MILTON FINNEY, M.D.
AMA Arch Intern Med. 1955;95(2):202-218.
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CHLORPROMAZINE ( 10-[ -dimethylaminoprophyl] - 2 - chlorophenothiazine hydrochloride) is a phenothiazine derivative which has been reported to be effective in the treatment of a wide variety of clinical conditions.* Preliminary observations have indicated that it is useful in neuroses and psychoses, nausea and vomiting, shock,11 and as an agent to augment the effect of anesthetics and opiates.12 The purpose of the present report is to present a summary of results obtained when chlorpromazine was used for the treatment of neuropsychiatric disorders, for nausea and vomiting of diverse causation, and for intractable hiccoughs. In these studies each patient served as his own control.
The results reported for the neuropsychiatric patients should be considered qualitative rather than quantitative observations. The primary purpose of this aspect of the study was an attempt to estimate therapeutic applicability in varied neuropsychiatric disorders. In addition, attempts were made to establish the maximum, as well as the most
. . . [Full Text PDF of this Article]
Author Affiliations
Houston, Texas
From Departments of Medicine, Psychiatry, and Pharmacology, Baylor University College of Medicine.
Footnotes
In the United States chlorpromazine was first designated as SKF #2601-A and is now called Thorazine; in Canada, England, France, and Italy it is called Largactil; in Germany, Megaphen, and in Argentina, Ampliactil.
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