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I. On a Fat-Splitting Enzyme in Urine and Its Relation to Pancreas

MARTIN M. NOTHMAN, M.D.; JOSEPH H. PRATT, M.D.; ALLAN D. CALLOW, M.D.

AMA Arch Intern Med. 1955;95(2):224-230.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE NUMBER of studies on fat-splitting enzymes in the urine is very small. Papers on urinary enzymes in general hardly mention the possibility of their presence. The methods used are open to objection. It is, therefore, not surprising that the results are contradictory. The latest and rather comprehensive German paper, by Zorn,¹ published in 1937, denies the presence of a fat-splitting enzyme in the urine of healthy persons. In the American literature of the past 20 years we did not find any reference except for a citation of Zorn in Bockus' "Handbook of Gastroenterology."²

In our early investigation of pancreatic enzymes in blood and urine under normal, pathological, and experimentally produced conditions in men and animals ³ we developed a method for the determination of a fat-splitting enzyme in the blood and adapted it for the use in the urine. The principle of the method is that lipase splits olive . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Medical and Surgical Departments of the New England Center Hospital and Tufts College Medical School.

Footnotes
Supported by a grant-in-aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council and by a grant from the Charlton Research Fund, Tufts College Medical School.

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