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Rapid Development of Resistance in Vivo and in Vitro

ROBERT J. ROANTREE, M.D.; LOWELL A. RANTZ, M.D.

AMA Arch Intern Med. 1955;95(2):320-325.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

BECAUSE the Staphylococcus has the ability to develop resistance when exposed to currently used antibiotics, the treatment of staphylococcal disease, and particularly of endocarditis, is most difficult. A recent case well illustrates the emergence of a strain resistant to erythromycin. In vitro studies help to clarify the problem and show that resistant variants may appear from the great majority of staphylococcal strains.

The case described here is of interest from several other viewpoints. The causative organism was a coagulase-negative Staphylococcus albus. Infection was discovered following mitral valvotomy, a fairly rare occurrence,* despite the theoretic probability of such an event. The immediate cause of death seemed to be the occlusion of the mitral orifice by a large vegetation.

REPORT OF A CASE

B. B., a 52-year-old white housewife, reentered Stanford University Hospital on May 11, 1954, for mitral valvotomy. She had undergone rectal polypectomy and cryptectomy on April 7, 1954, without . . . [Full Text PDF of this Article]

Author Affiliations
San Francisco

From the Department of Medicine, Stanford University School of Medicine.

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