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OLOF H. PEARSON, M.D.; CHARLES D. WEST, M.D.; MIN CHIU LI, M.D.; JOHN P. MACLEAN, M.D.; NORMAN TREVES, M.D.

AMA Arch Intern Med. 1955;95(2):357-364.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

VARIOUSe environment which result in therapeutic benefit in patients with metastatic mammary cancer are illustrated. The use of calcium excretion as a practical means of evaluating tumor growth in bone is shown. The results of surgical castration, bilateral adrenalectomy, and hypophysectomy are presented. A physiological basis for these methods of treatment is presented by demonstrating that certain hormones of the ovary, adrenal, and pituitary glands are important in maintaining the growth of mammary cancer. The therapeutic effects of cortisone, estrogens, and androgens are illustrated, with emphasis on the situations in which these hormones are most likely to be of benefit. The sequence of therapeutic measures which is most likely to produce optimum benefit is outlined. . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Division of Clinical Investigation, Sloan-Kettering Institute for Cancer Research, and the Medical and Breast Services, Memorial and James Ewing Hospitals.

Footnotes
Shown as a scientific exhibit of the Section on Experimental Medicine and Therapeutics at the 103rd Annual Meeting of the American Medical Association, San Francisco, June 21-25, 1954.

These studies were supported in part by grants from the National Cancer Institute, National Institutes of Health, United States Public Health Service, C-925(C6), C-2126; the United States Atomic Energy Commission; the American Cancer Society, Inc., and the Damon Runyon Memorial Fund.

The authors wish to acknowledge the collaboration of Drs. Henry T. Randall, Bronson S. Ray, Willet F. Whitmore, Jr., Charles C. Harrold, Frank E. Adair, George C. Escher, James Green, John Finkbeiner, Joseph Farrow, Guy Robbins, Alfred A. Fracchia, Charles Breed Jr., Dorothy Sved, Richard Kaufman, and Jerome A. Urban.

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