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Pathogenesis, Clinical Manifestations, and Treatment

GORDON B. MYERS, M.D.; LLOYD T. ISERI, M.D.

AMA Arch Intern Med. 1955;95(4):503-537.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

I. CLASSIFICATION

The classification of abnormalities of water volume and/or sodium concentration is presented in Table 1.¹ From the standpoint of pathogenesis, the abnormalities may be di- vided into two groups: (a) conditions characterized by a primary alteration in extracellular volume or sodium concentration and a secondary shift of water between interstitial tissue and cells to effect equilibrium of osmotic pressure;* (b) conditions characterized by a primary cellular disturbance, with alteration in the content or concentration of osmotically active intracellular electrolytes and a parallel change in the osmolarity of the extracellular compartment. The pathogenesis and clinical manifestations of these two groups are presented separately.

II. PATHOGENESIS OF PRIMARY

ABNORMALITIES

Pathogenesis of primary abnormalities of water volume and sodium concentration is given in Table 2. The basic predisposing factor in the dehydration syndrome is fluid loss. If losses continue unchecked, the syndrome likely to develop will depend partly upon the . . . [Full Text PDF of this Article]

Author Affiliations
Detroit

From the Department of Medicine of Wayne University and City of Detroit Receiving Hospital.

Footnotes
Supported in part by grants from the Michigan Heart Association and National Institutes of Health.

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