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Review of Sixty-One Proved Cases

E. G. BROWNELL, M.D., M.R.C.P.

AMA Arch Intern Med. 1955;95(5):699-704.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Multiple myeloma is a well-known clinically distinctive malignant disease of the skeleton, characterized by multiple osteolytic plasma-cell tumors of bone and a proliferation of plasma cells within the marrow. These tumors have a predilection for the bones where active blood formation takes place in the adult; i. e., the sternum, ribs, vertebral bodies, skull, bones of the shoulder girdle, pelvis, and upper ends of the humeri and femora.

Although the substance now known as Bence-Jones protein was first discovered in 1845 by Dr. Henry Bence-Jones ¹ and von Rustizky ² first described the condition mul-tiples Myelom in 1873, it was not till 1889 that Kahler³ associated this disease with the occurrence of Bence-Jones proteinuria. Since then, excellent reviews by Geshickter and Copeland,⁴ Bayrd and Heck,⁵ and Lichtenstein and Jaffe ⁶ have helped systematize our present knowledge of this disease.

This discussion is based on 61 cases . . . [Full Text PDF of this Article]

Author Affiliations
Winnipeg, Man., Canada

Assistant Physician, Winnipeg General Hospital; Department of Internal Medicine, Winnipeg Clinic.

Footnotes
Read before the Twenty-Fifth Annual Meeting of the Royal College of Physicians of Canada at Winnipeg, Canada, Oct. 22, 1954.

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