This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Deficiency

BRACHA RAMOT, M.D.; BASIL ANGELOPOULOS, M.D.; KARL SINGER, M.D.

AMA Arch Intern Med. 1955;95(5):705-712.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Until recently, male persons with a severe hemorrhagic diathesis characterized by (1) a prolonged clotting time, (2) normal Quick plasma prothrombin time, but (3) a poor prothrombin consumption were unhesitatingly diagnosed as suffering from classic hemophilia. This disease is still widely attributed to a deficiency of antihemophilic factor (AHF)¹ essential for the formation of blood thromboplastin. However, it has been emphasized that the demonstrable decrease of AHF activity in these patients may be functional rather than real, owing to the presence of an inhibitor (antithromboplastin).²

In 1952, Aggeler and co-workers³ described a syndrome, clinically and genetically indistinguishable from classic hemophilia, which is apparently caused by the absence or marked diminution of a previously unrecognized plasma constituent. They named this factor plasma thromboplastin component (PTC). PTC is also essential for the formation of blood thromboplastin. The PTCdeficiency syndrome is now known under a variety of names, such as . . . [Full Text PDF of this Article]

Author Affiliations
Tel-Aviv, Israel; Athens, Greece; Chicago

From the Department of Hematologic Research, Medical Research Institute, Michael Reese Hospital; Ruth Berger Reader Fellow, Hematology Research Foundation (Dr. Ramot); Lederle Research Fellow and Lecturer in Medicine, University of Athens (Dr. Angelopoulos); Director, Department of Hematologic Research( Dr. Singer).

Footnotes
This work was supported in part by the Hulda B. and Maurice L. Rothschild Foundation for Scientific Research.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?