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The Minot Lecture

HARVEY A. ITANO, M.D., Ph.D.

AMA Arch Intern Med. 1955;96(3):287-297.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The role played by Dr. William B. Castle, the first Minot lecturer, in stimulating the initial studies of hemoglobin in sickle-cell anemia is not generally known. It was his description, in 1945, of the effect of oxygen and carbon dioxide on sickling, in Dr. Linus Pauling's presence, which prompted Dr. Pauling to postulate that an abnormal hemoglobin was present in the sickling cells.¹ The following year, Dr. Pauling suggested that I begin the investigation which culminated in the detection of an inherited abnormal hemoglobin in sickle-cell anemia and sickle-cell trait.² By 1951 two more abnormal hemoglobins (Figs. 1-5) were found to be associated with sicklecell disease.* By 1953, ten distinct hereditary clinical states were known to be associated with abnormal hemoglobin metabolism.⁵ During the past year five more abnormal hemoglobins have been found, two in clinical states resembling Cooley's anemia and two in asymptomatic states. While part of what . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md.

Clinical Biochemical Research Section, Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health.

Footnotes
Submitted for publication June 30, 1955.

Read before the Section on Experimental Medicine and Therapeutics at the 104th Annual Meeting of the American Medical Association, Atlantic City, June 8, 1955.

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